| Acronym | Definition |
|---|
| DDO | Dungeons & Dragons Online |
| DDO | Dollard des Ormeaux (Montreal District) |
| DDO | Drawing and Disbursing Officer (various organizations) |
| DDO | Dynamic Data Object |
| DDO | Discount Drugs Online |
| DDO | Dynamic Drive Overlay |
| DDO | Dubberly Design Office (San Francisco, CA) |
| DDO | Double Die Obverse (numismatics) |
| DDO | Deputy Director of Operations (US CIA) |
| DDO | Deputy District Officer (Pakistan) |
| DDO | Diocesan Director of Ordinands (Church of England) |
| DDO | Dogues de l'Ouest (French: Dogs of the West) |
| DDO | Direct Debit Option (payment method) |
| DDO | Designated Detention Officer (UK police) |
| DDO | Distillate Diesel Oil |
| DDO | Discrete Digital Output (NASA) |
| DDO | Diocesan Development Office (Catholic Church) |
| DDO | Digital Data Objects |
| DDO | Disobeying a Direct Order |
| DDO | Digital Data Out |
| DDO | Dual Docked Operation (US NASA) |
| DDO | Departmental Duty Officer |
| DDO | Démarche Départementale d'Observation (French: Departmental Process Observation) |
| DDO | Daily Dose of Optimism (blog; investing) |
| DDO | Designated Days Off |
| DDO | District Directorate Officer |
| DDO | Direct Dialing Overseas (Nortel) |
| DDO | Duty District Officer |