| Acronym | Definition |
|---|
| COSMIC | Constellation Observing System for Meteorology, Ionosphere and Climate (collaboration project between US University Corporation for Atmospheric Research and ROC National Space Program Office) |
| COSMIC | Computer Software Management and Information Center |
| COSMIC | Concepts and Operations for Space and Missile Defense Integration Capabilities |
| COSMIC | The Common Software Measurement International Consortium |
| COSMIC | North Atlantic Treaty Organization (NATO) Security Category (US DoD) |
| COSMIC | Country Specific Model for Intertemporal Climate |
| COSMIC | Common System Main Interconnecting Frame |
| COSMIC | Coherent Optical System of Modular Imaging Collectors |
| COSMIC | Component Synthesis with Model Integrated Computing |
| COSMIC | Computer Software Management Information Center |
| COSMIC | Comparing Options in Secondary Mathematics: Investigating Curriculum (NSF-funded research project) |
| COSMIC | Chamber Orchestra of Southern Marylnd in Concert |
| COSMIC | Centers For Ocean Surveillance & Maritime Information Coordination |
| COSMIC | Corporate Sustainability Management in Indian Companies (Adelphi; Berlin, Germany) |
| COSMIC | Catalogue of Somatic Mutation in Cancer (database) |
| COSMIC | Conservation of Ancient Monuments in Cultivation |