| Acronym | Definition |
|---|
| CLU | California Lutheran University (Thousand Oaks, California) |
| CLU | Chartered Life Underwriter (insurance) |
| CLU | Cluster (object-oriented programming language) |
| CLU | Christian Leadership University (online college) |
| CLU | Change in Land Use (zoning; various locations) |
| CLU | Claremont Lincoln University (Claremont, CA) |
| CLU | Command Line Utility |
| CLU | Civil Liberties Union |
| CLU | Codified Likeness Utility (Tron) |
| CLU | Community Labor United (various locations) |
| CLU | Command & Launch Unit |
| CLU | Container Launch Unit |
| CLU | Central Labor Union |
| CLU | Community Land Unit (UK) |
| CLU | Concept Lumière Urbaine (French: Urban Light Concept; design contest) |
| CLU | Circuit Line Up |
| CLU | Communion and Liberation University |
| CLU | Common Logic Unit |
| CLU | Constant Linear Unit |
| CLU | Conditional Location Update |
| CLU | Containerized Latrine Unit |
| CLU | Consejo de Latinos Unidos |