| Acronym | Definition |
|---|
| COMET | Carvedilol or Metoprolol European Trial (clinical study) |
| COMET | Cisco Complete Optical Multiservice Edge and Transport |
| COMET | Commercialising Emerging Technologies (Australian mining) |
| COMET | Cooperative Program for Operational Meteorology, Education and Training (University Corporation for Atmospheric Research) |
| COMET | Comité d'Organisation des Manifestations Économiques et Touristiques (French: Organizing Committee for Economic and Tourism Events) |
| COMET | Complete Optical Multiservice Edge and Transport |
| COMET | Commercial Experiment Transporter |
| COMET | Concurrent Object Modeling and Architectural Design Method (software design method for concurrent, distributed, and real time applications) |
| COMET | California Online Mathematics Education Times (weekly journal) |
| COMET | Commercial Education and Training (Canada) |
| COMET | Construction Materials Engineering and Testing |
| COMET | Cost Of Manpower Estimating Tool |
| COMET | Computational Mechanics Testbed |
| COMET | Complementary Medicines Transition Database |
| COMET | COmmunication by MEteor Trails (meteor burst communications system) |
| COMET | Compressor Operations Management Expert Tool |
| COMET | Collection en Orbite de Matiere Extra Terrestre |
| COMET | Command Experience & Training |
| COMET | Cisco Optical Multiservice Edge and Transport |
| COMET | Compuscan Optical Message Entry Terminal |
| COMET | Common Environment for Testing |
| COMET | Commander's Maintenance Evaluation Team (US Army) |