| Acronym | Definition |
|---|
| DLE | Datalife Engine (software) |
| DLE | Discoid Lupus Erythematosus |
| DLE | Data Link Escape |
| DLE | Direct Labor Efficiency (work formula) |
| DLE | Digital Line Equipment |
| DLE | Data Line Escape |
| DLE | Data Length Escape |
| DLE | Droits et Libertés dans les Églises (French: Rights and Liberties in the Churches) |
| DLE | Digital Library Evaluation |
| DLE | Dry Low Emission |
| DLE | Disseminated Lupus Erythematosus (same as Systemic Lupus Erythematosus) |
| DLE | Digital Local Exchange |
| DLE | Didactique des Langues Étrangères (French: Teaching of Foreign Languages) |
| DLE | Distance Learning Exchange (Pennsylvania Department of Education) |
| DLE | Dual Language Education |
| DLE | Dynamic Lightpath Establishment (IEEE) |
| DLE | Department of Labor & Employment (Colorado) |
| DLE | Digital Loop Electronics (Telcordia) |
| DLE | Distributed LAN Emulation |
| DLE | Deserts Like Eden |
| DLE | Ductility Level Earthquake |
| DLE | Disk List Entry (Amanda/Zmanda Backup Software) |
| DLE | Double-Line Electro (stamp collecting; a form of precancellation) |
| DLE | Drug Laboratory Effect |
| DLE | Detailed Ledger Entry |
| DLE | Development Laboratory Environment |
| DLE | Diverse Learning Environments (survey) |
| DLE | Direct Lightning Effects |
| DLE | Department of Logistics and Engineering |
| DLE | Distance Learning and Education |
| DLE | Defense Liaison Element (US Army) |
| DLE | Dynamic Labile Equilibrium |
| DLE | Degree Level Expectations (Canada) |
| DLE | Distinctive Ladies of Elegance |
| DLE | Divorce Level Event |