| Acronym | Definition |
|---|
| DESI | Direction de l'Enseignement de Service en Informatique (French: Directorate of Education in Computer Service; Canada) |
| DESI | Drug Efficacy Study Implementation |
| DESI | Desorption Electrospray Ionization |
| DESI | Diplôme d'Etudes Supérieures d'Instituteur (French: Graduate Teaching Diploma; various universities) |
| DESI | Department of Economic and Social Information (Estonia) |
| DESI | Division for Economic and Social Information (UN) |
| DESI | Digital End-Speed Indicator |
| DESI | Davenport Educational System, Incorporated |
| DESI | Duke Energy Solutions, Inc. |