| Acronym | Definition |
|---|
| DIR | Directory |
| DIR | Director |
| DIR | Direction |
| DIR | Department of Industrial Relations |
| DIR | Directive |
| DIR | Direct(ed) |
| DIR | Director's Office |
| DIR | Directional |
| DIR | Department of International Relations (various organizations) |
| DIR | Directorate |
| DIR | Direction Interdépartementale des Routes (French: Interdepartmental Directorate of Roads) |
| DIR | Doing It Right (SCUBA diving) |
| DIR | Data in Register (computing) |
| DIR | Daiwa Institute of Research Ltd (Japan) |
| DIR | Deformable Image Registration |
| DIR | Direct and Indirect Remuneration (Medicare) |
| DIR | Directory File |
| DIR | Data Input Register |
| DIR | Dépannage Informatique Rapide (French computer repairs) |
| DIR | Dissimilatory Iron Reduction |
| DIR | Data Information Request (various locations) |
| DIR | Darovitih Informaticara Rijeke (Croatian: Rivers Talented Informatics Association) |
| DIR | Digital Instrumentation Recorder (Sony) |
| DIR | Diagnostic and Interventional Radiology |
| DIR | Domestic Incident Report (NYPD) |
| DIR | Digital Audio Interface Receiver |
| DIR | Dimension Informatique Réalisations (French: Dimension Data Projects) |
| DIR | Doctors Insurance Reciprocal |
| DIR | Directly Interpretable Representation |
| DIR | Detailed Implementation Regulations (China) |
| DIR | Differentiated Reliability |
| DIR | Defense Intelligence Report |
| DIR | Division of International Relations |
| DIR | Drug Intervention Record (UK) |
| DIR | Digital Image Restoration |
| DIR | Detection, Isolation, Recovery |
| DIR | Dad in Room (chat) |
| DIR | Disassembly Inspection Report |
| DIR | Data Item Requirement |
| DIR | Depot Inspection & Repair |
| DIR | Domestic Imagery Requirement (FEMA) |
| DIR | Daily Information Report |
| DIR | Discovery Investigation Request |