| Acronym | Definition |
|---|
| DEFA | Diplôme d'Etat Relatif aux Fonctions d'Animation (French: State Diploma on the Functions of Animation) |
| DEFA | Diplôme d'Etudes Fondamentales en Architecture (French: Diploma of Basic Architecture Studies) |
| DEFA | Direção de Emigração e Fronteras de Angola (Portuguese: Directorate for Migration and Frontiers of Angola, Luanda) |
| DEFA | Département Énergétique Fondamentale et Appliquée (French: Fundamental and Applied Energetics Department) |
| DEFA | Deutsche Filmakademie (German Film Academy) |
| DEFA | DharmaNet Electronic Files Archive (Buddhist study) |
| DEFA | Detect Early Fluorescent Antigens |
| DEFA | Driver-Enriched Fuel Assembly |