| Acronym | Definition |
|---|
| DISCO | Discothèque |
| DISCO | Distribution Company (Pakistan) |
| DISCO | Distribution Company |
| DISCO | Defense Industrial Security Clearance Office |
| DISCO | Diagnostic Interview for Social and Communication Disorders (psychology) |
| DISCO | Design and Implementation of Symbolic Computation Systems (ACM Symposium) |
| DISCO | Discrete Surface Charge Optimization (algorithm) |
| DISCO | Data Interface to the Sun at Capodimonte Observatory (Naples, Italy) |
| DISCO | Defense Investigative Service Contract Office |
| DISCO | Database Integrated Servers Using Constraints |
| DISCO | Defense Investigative Security Clearance Office |
| DISCO | Division Information System Control Officer |
| DISCO | Distribution/Consolidation |
| DISCO | Document Imaging System for Correspondence Operation (Sprint) |
| DISCO | Domestic Inter-Satellite Coordination Organization |
| DISCO | Dancer's Integrated Sonic Celebration Oscillator (gaming, World of Warcraft) |
| DISCO | Domestic International Satellite Consideration Order |