| Acronym | Definition |
|---|
| ENC | Enclosure |
| ENC | Encoded (File Name Extension) |
| ENC | École Nationale de Commerce (French: National School of Commerce) |
| ENC | Eastern North Carolina |
| ENC | Eastern Nazarene College |
| ENC | Épagneul Nain Continental (French: Continental Toy Spaniel) |
| ENC | École Normale Catholique (French: Normal Catholic School) |
| ENC | European Nations Championship (various organizations) |
| ENC | École Nationale des Chartes (French: National School of Charters) |
| ENC | Eisenhower National Clearinghouse for Mathematics and Science Education |
| ENC | Egg Nutrition Center (Washington, DC) |
| ENC | Enti Non Commerciali (Italian: Non-Commercial Entity) |
| ENC | Mime-Encoded (virus scanners) |
| ENC | European Nations Cup (rugby) |
| ENC | Ecs Network Configurator |
| ENC | Encyclopedia |
| ENC | Encrypting |
| ENC | Encoding |
| ENC | Equality North Carolina (advocacy) |
| ENC | Enchanter (Everquest) |
| ENC | Examen National Classant (French: National Ranking Examination) |
| ENC | Essences Naturelles Corses (French: Natural Essences Corsicans) |
| ENC | Electronic Navigation Chart |
| ENC | Effects Not Cleared (banking) |
| ENC | English News Channel (website) |
| ENC | École Nantaise de Coiffure (French: Nantes School of Hairdressing; Nantes, France) |
| ENC | European Networking Center |
| ENC | Equivalent Noise Charge |
| ENC | Electronic Noise Cancellation |
| ENC | Encuentro Nacional de Computación |
| ENC | Emergency News Center (various organizations) |
| ENC | Engenharia de Computação (Portuguese: Computer Engineering) |
| ENC | Chief Engineman (Naval Rating) |
| ENC | Electroencephalography Technician (US Navy) |
| ENC | École Nantaise de Cuivres (French: Nantes School of Brass; Nantes, France) |
| ENC | Enlistment Cancelled (US Navy) |
| ENC | Environment North Carolina |
| ENC | Enterprise Network Carrier (Convergent) |
| ENC | Exxon Nuclear Company, Inc. |
| ENC | ECCM Network Controller |
| ENC | Excess Net Capital |
| ENC | Enforced Collections |
| ENC | Enteral Nutrition Council |