| Acronym | Definition |
|---|
| FDE | Full Disk Encryption |
| FDE | Fractional Diffusion Equation |
| FDE | Federal Directorate of Education (Pakistan) |
| FDE | Financial Data Extraction (various companies) |
| FDE | Fédération Départementale d'Énergie (French: Departmental Federation of Energy) |
| FDE | First Demyelinating Event |
| FDE | Floppy Disk Emulation |
| FDE | Folder Redirection Extension |
| FDE | Folder Redirection Editor |
| FDE | Frequency Domain Experiments |
| FDE | Frequency Domain Equalization |
| FDE | FedEx |
| FDE | Fonctions et Dysfonctions Épithéliales (French: Epithelial Functions and Dysfunctions) |
| FDE | Fundação para o Desenvolvimento da Educação (Brazil) |
| FDE | Flat Dark Earth |
| FDE | Fixed Drug Eruption |
| FDE | France Développement Électronique (French computer engineering company) |
| FDE | Fault Detection and Exclusion |
| FDE | France Distribution Express (est. 1999) |
| FDE | Florida Defenders of the Environment |
| FDE | Florida Digital Educator (program) |
| FDE | Functional-Differential Equation |
| FDE | Full Duplex Ethernet |
| FDE | Force Development Evaluation |
| FDE | Fixed Duration Employee |
| FDE | Fabrications Distributions Études (French distribution company) |
| FDE | Fluid Dynamics Experiment |
| FDE | Finite Difference Equation(s) |
| FDE | Flight Data Entry |
| FDE | Final Destination Evils (gaming clan) |
| FDE | Force Deployment Estimator |
| FDE | First Data Europe |
| FDE | Flight Dynamics Engineer |
| FDE | Failure Detection Electronics |
| FDE | Fault Disconnection Equipment |
| FDE | Fetch-Decode-Execute (computer systems) |
| FDE | Force Development Experimentation |
| FDE | Fetal Drug Effects |
| FDE | Frequency Domain Encoding |
| FDE | Functional Data Element |
| FDE | Fuel-Damage Equation |
| FDE | Fuzzy Duck Explorer |