| Acronym | Definition |
|---|
| DU | Dutch |
| DU | Dubai |
| DU | Duplex |
| DU | Duke University |
| DU | Delhi University |
| DU | Dubrovnik, Croatia (license plate) |
| DU | Doctor of the University |
| DU | University of Denver |
| DU | Dhaka University |
| DU | Ducks Unlimited |
| DU | Drexel University |
| DU | Dictionary of the Underworld |
| DU | Diplôme d'Université (French: University Diploma) |
| DU | Democratic Underground (website) |
| DU | University of Dhaka (Bangladesh) |
| DU | Display Unit |
| DU | Denver University |
| DU | Dual Use (Army National Guard) |
| DU | Duquesne University (Pittsburgh, PA, USA) |
| DU | Detailed Understanding |
| DU | Depleted Uranium |
| DU | Deyrnas Unedig (Welsh: United Kingdom) |
| DU | Development Unit |
| DU | Dwelling Unit (building) |
| DU | Drake University (Des Moines, Iowa) |
| DU | Duodenal Ulcer |
| DU | Disk Usage |
| DU | Dominican University |
| DU | Drew University |
| DU | Delta Upsilon (fraternity) |
| DU | Disk Utility |
| DU | Denison University |
| DU | Davenport University |
| DU | Data Unit |
| DU | Distribution Unit |
| DU | Documento Unico |
| DU | Dillard University (New Orleans, LA) |
| DU | Drury University |
| DU | Delivery Unit |
| DU | Dog Unit |
| DU | Danske Universiteter (Copenhagen, Denmark) |
| DU | Dobson Units |
| DU | Digital University |
| DU | Digital Unit |
| DU | Desktop Underwriter (loans and mortgages tool) |
| DU | Daily Universe (college newspaper at BYU) |
| DU | Discounted Utility |
| DU | Disk Used |
| DU | Dobson Unit(s) |
| DU | Diesel United Ltd. (Japan) |
| DU | Decision Unit |
| DU | Widespread Dust (METAR obscuration) |
| DU | Documentation Unit |
| DU | Daugavpils Universitate (Latvia) |
| DU | Dangerous, Undetected Failure |
| DU | Distance Uniform (signal or signal set) |
| DU | Diagnosis Undetermined |
| DU | Derivative with respect to the variable U |
| DU | Duplicator Unit |
| DU | Discardable Unit (logistic analyses) |
| DU | Dependable Undertaking |