| Acronym | Definition |
|---|
| ESE | Exceptional Student Education (Florida) |
| ESE | Erasmus School of Economics (Erasmus University Rotterdam; Netherlands) |
| ESE | Extensible Storage Engine (Microsoft Exchange Server) |
| ESE | Elementary and Secondary Education (various locations) |
| ESE | Economic, Social and Environmental |
| ESE | Easy Serving Espresso |
| ESE | East-South-East |
| ESE | Empirical Software Engineering |
| ESE | Embedded Secure Element (mobile technology) |
| ESE | Earth Science Enterprise (NASA) |
| ESE | Enterprise Systems Engineering |
| ESE | Enhanced Systems Engineering |
| ESE | Extensible Storage Engine |
| ESE | Error in Simple Expression |
| ESE | Error Status Element |
| ESE | Event Status Enable |
| ESE | Eastern States Exposition (West Springfield, MA) |
| ESE | Enseignement Supérieur à l'Etranger (French: Higher Education Abroad) |
| ESE | Environmental Science and Engineering |
| ESE | Écologie et Santé des Écosystèmes (French: Ecology and Health of Ecosystems) |
| ESE | Exonic Splicing Enhancer |
| ESE | Écologie, Systématique, Évolution (French: Ecology, Systematics, Evolution; laboratory) |
| ESE | École Supérieure d'Electricité (French electrical school) |
| ESE | Electronic Stock Exchange |
| ESE | Electronic Support Equipment (various locations) |
| ESE | European Seafood Exhibition (tradeshow) |
| ESE | European Solar Engineering (Belgium) |
| ESE | Electronic Security Equipment |
| ESE | E-Commerce Search Engine |
| ESE | Entrance Skin Exposure (medical x-ray) |
| ESE | Enterasys Systems Engineer |
| ESE | Early Streamer Emitter (ligthning protection) |
| ESE | Eclipse Summit Europe |
| ESE | Electrical Support Equipment (US NASA) |
| ESE | Experimental School Environment |
| ESE | Expert Systems Environment |
| ESE | Exceptional/Special Education |
| ESE | Electronic Surveillance Enhancement |
| ESE | Expert Social pour l'Entreprise (French: Social Enterprise Expert) |
| ESE | Escola de Sargentos do Exército (Portugal) |
| ESE | Equipment Service Employee (airline employee) |
| ESE | Enhanced Secure Environment (anti-cheat gaming software) |
| ESE | EVA Support Equipment |
| ESE | Engineer Support Equipment (Army) |
| ESE | Exact Signed English |
| ESE | Electronic Security Europe |
| ESE | École Supérieure de l'Entreprise (French: Graduate School of Business) |
| ESE | Europe Sécurité Événements (French security company) |
| ESE | External Speed Expansion |
| ESE | Enhanced Spectrum Efficiency |
| ESE | European Society of Endontology |