| Acronym | Definition |
|---|
| GDI | Global Domains International (web hosting) |
| GDI | Global Defense Initiative (Command and Conquer game) |
| GDI | Global Defense Initiative (Command & Conquer game) |
| GDI | Graphics Device Interface |
| GDI | Gasoline Direct Injection |
| GDI | Gottlieb Duttweiler Institute (Switzerland) |
| GDI | Gender-related Development Index |
| GDI | Graphical Device Interface |
| GDI | Gardner Denver, Inc. (Wayne, PA) |
| GDI | Global Domains International |
| GDI | Gross Domestic Income (economics) |
| GDI | GDP Dissociation Inhibitor |
| GDI | Gender Development Index |
| GDI | Gamma Delta Iota (fraternity) |
| GDI | Garage Doors, Inc. (San Jose, CA) |
| GDI | God Damn Independent (slang for someone not living in dorms, housing, or Greek System) |
| GDI | Green Design Institute |
| GDI | God Damn It |
| GDI | Graphical Display Interface |
| GDI | Groupement de Défense Internationale (French: Global Defense Initiative) |
| GDI | Getting Data In |
| GDI | Gonzaga Debate Institute (debate camp) |
| GDI | Gosh Darn It |
| GDI | Gosh-Darned Independent (polite form) |
| GDI | Generic Display Interface |
| GDI | General Delegation of Independents |