| Acronym | Definition |
|---|
| ESME | École Spéciale de Mécanique et d'Électricité (French: Special School of Mechanics and Electricity) |
| ESME | Ecole Speciale de Mecanique et d'Electricite (French engineering school) |
| ESME | European Securities Markets Expert Group |
| ESME | External Short Message Entity (external sources and sinks of short messages) |
| ESME | Early Summer Meningoencephalitis (disease) |
| ESME | Energy Efficiency in Small and Medium-Sized Enterprises |
| ESME | Educational Statistics, Measurement and Evaluation (Rutgers University; New Jersey) |
| ESME | Enhanced Simulation Modeling Environment |