| Acronym | Definition |
|---|
| DRU | Druid (Everquest) |
| DRU | Dezvoltarea Resurselor Umane (Romanian: Human Resources Development) |
| DRU | Doctoral/Research University (school classification) |
| DRU | Disaster Resistant University |
| DRU | Direct Reporting Unit |
| DRU | Disaster Response Unit (various organizations) |
| DRU | Device Recording Unit |
| DRU | Dvd Rewritable Unit |
| DRU | Data Rollup Utility |
| DRU | Direct Response Unit (INMARSAT) |
| DRU | Dynamic Reference Unit |
| DRU | Diplôme de Recherche Universitaire (French: University Research Degree) |
| DRU | Differential Rate Unit (energy measurement) |
| DRU | Digital Radio Unit |
| DRU | Da Roxor United (gaming clan) |
| DRU | Data Recovery Unit |
| DRU | Dansk Rugby Union (Danish Rugby Club) |
| DRU | Development Review Unit (various locations) |
| DRU | Demolition Research Unit (US Navy) |
| DRU | Desert Research Unit |
| DRU | Distal Radio-Ulnar |
| DRU | Data Retrieval Unit |
| DRU | Data Receiver Unit |
| DRU | Data Reformatter Unit |
| DRU | Depot Replaceable Unit |
| DRU | Demountable Refrigeration Unit |
| DRU | Double Radio Unit |