| Acronym | Definition |
|---|
| HEM | Hermann (Amtrak station code; Hermann, MO) |
| HEM | Halk Egitimi Merkezi (Turkish: Public Education Center) |
| HEM | Home Education Magazine |
| HEM | Home Energy Management |
| HEM | Higher Education Management (various schools) |
| HEM | Huber Engineered Materials (Atlanta, GA) |
| HEM | High Efficiency Module |
| HEM | Healthcare Emergency Management (various schools) |
| HEM | Home Energy Magazine (Berkeley, CA) |
| HEM | High Energy Milk |
| HEM | Honeywell Electronic Materials (various locations) |
| HEM | Historical Electronics Museum (Museum of electronics including radar, military, and microwave devices; Linthicum, Maryland) |
| HEM | Hollywood Entertainment Museum |
| HEM | High Efficiency Matching |
| HEM | Healthcare Environmental Manager |
| HEM | Heavy Equipment Maintenance |
| HEM | Human Exposure Modeling |
| HEM | Heat Exchange Method |
| HEM | Hybrid Electromagnetic Wave |
| HEM | Human Eradication Mode (TV show South Park) |
| HEM | High Energy Magic (Discworld) |
| HEM | Human Epidermal Model |
| HEM | Historic Engineering Marker (Australia) |
| HEM | Honeywell Energy Manager (commercial building engineering) |