| Acronym | Definition |
|---|
| HERO | Health and Environmental Research Online (US EPA) |
| HERO | Houston Equal Rights Ordinance (Houston, TX) |
| HERO | Hemodialysis Reliable Outflow (dialysis catheter) |
| HERO | Higher Education and Research Opportunities (UK) |
| HERO | Hazards of Electromagnetic Radiation to Ordnance |
| HERO | Health Enhancement Research Organization |
| HERO | Home Economics Related Occupations (Future Homemakers of America) |
| HERO | High Efficiency Reverse Osmosis |
| HERO | Historic Endurance Rallying Organisation (UK) |
| HERO | Highway Emergency Response Operator (Georgia Department of Transportation, Atlanta) |
| HERO | High Energy Replicated Optics (NASA) |
| HERO | Hyper Extremely Red Object (astronomy) |
| HERO | Helicopter Emergency Rescue Operation (computer game; aka Helicopter Equipped Rescue Operation) |
| HERO | Home Educators Resource Organization |
| HERO | Health and Environmental Rescue Organization |
| HERO | Honesty, Empathy, Respect, Open-Mindedness |
| HERO | Hyperspectral Environment and Resource Observer (Canadian Space Agency satellite) |
| HERO | Highway Emergency Response Operations (Australia) |
| HERO | Heart of England Recorder Orchestra (Coventry, England) |
| HERO | Home Energy and Resources Organization |
| HERO | Helping Everyone Realize Opportunities |
| HERO | Helicopter Emergency Reconnaissance Observer (USACE) |