| Acronym | Definition |
|---|
| HPCS | High Performance Computing and Simulation (symposium) |
| HPCS | High Performance Computing Systems |
| HPCS | High Productivity Computing Systems |
| HPCS | High Performance Computing Symposium |
| HPCS | High Performance Communication Server |
| HPCS | Harry Potter and the Chamber of Secrets (book/movie) |
| HPCS | Hippotherapy Professional Clinical Specialist (American Hippotherapy Association; Damascus, PA) |
| HPCS | Hewlett-Packard Cloud Services (computing) |
| HPCS | High Pressure Core Spray system (commercial nuclear power - Boiling Water Reactor, BWR Type) |
| HPCS | Hydridopolycarbosilane |