| Acronym | Definition |
|---|
| HPE | Honda Power Equipment (Swepsonville, NC) |
| HPE | Hewlett Packard Enterprise Company (Palo Alto, CA) |
| HPE | Health and Physical Education (various organizations) |
| HPE | Hitachi Power Europe |
| HPE | Haute Performance Énergétique (French: High Energy Performance) |
| HPE | Health Professional Education |
| HPE | High Performance Estate |
| HPE | High Performance Ethernet |
| HPE | Hennessey Performance Engineering |
| HPE | High Performance Equipment |
| HPE | High Performance Engineering |
| HPE | Holoprosencephaly |
| HPE | High Performance Estate (Lancia) |
| HPE | Hash-Programming-Environment (computing) |
| HPE | hed Planet Earth (band) |
| HPE | Heat Pipe Experiment |
| HPE | Histopathology Examination |
| HPE | Hexakis (NF2) Dipropyl Ether |
| HPE | High-Power Effects |
| HPE | Hemorrhage, Papilledema, Exudate |