| Acronym | Definition |
|---|
| HSK | Horst Schmidt Kliniken (German: Horst Schmidt Clinics) |
| HSK | Hanyu Shuiping Kaoshi (Chinese proficiency test) |
| HSK | Host Swap Kit |
| HSK | Handshake |
| HSK | Hauptabteilung für Die Sicherheit der Kernanlagen (Swiss Federal Nuclear Safety Inspectorate) |
| HSK | Herpes Simplex Keratitis |
| HSK | Hard Style Klowns (band) |
| HSK | Halu Mesru Savunma Kuvveti (aka Kurdistan Workers' Party) |
| HSK | High Speck Kareshi (Japan) |
| HSK | Hope Street Kids (pediatric cancer research) |
| HSK | Harambee Schools Kenya (UK) |
| HSK | Horrendous Space Kablooie (Calvin and Hobbes) |
| HSK | Hunt Suedhoff Kalamaros (Attorneys; Fort Wayne, IN) |
| HSK | Holystone Keeper (gaming, RF Online) |