| Acronym | Definition |
|---|
| HSL | Hue, Saturation, Lightness |
| HSL | Health Sciences Library (various universities) |
| HSL | Hormone-Sensitive Lipase |
| HSL | High Speed Link |
| HSL | Hessisches Statistisches Landesamt (German) |
| HSL | High Speed Launch (British powerboat; UK) |
| HSL | Hue Saturation Lightness |
| HSL | Host Service Location |
| HSL | Hybrid Silicon Laser |
| HSL | Health and Safety Laboratory (United Kingdom) |
| HSL | Health and Safety Law (various locations) |
| HSL | Heat Seal Lacquer (various companies) |
| HSL | Harwell Subroutine Library |
| HSL | Highly Sensitive List (goods) |
| HSL | Hybrid Solar Lighting |
| HSL | High School Liaison (various locations) |
| HSL | Hoge Snelheids Lijn (Dutch train) |
| HSL | Helicopter Antisubmarine Squadron Light (US Navy) |
| HSL | HERMES Softlab |
| HSL | Hazardous Substance List |
| HSL | Hardship Letter (immigration) |
| HSL | Hindustan Shipyard Ltd (India) |
| HSL | Holy Spirit Led |
| HSL | Home School Link |
| HSL | Hardware Simulation Laboratory (US NASA) |
| HSL | Helicopter Antisubmarine Warfare Light |
| HSL | Holland Sociaal Liggend (Dutch: Holland Social Landscape; cycling club) |
| HSL | Hydrographic-Survey Launch |
| HSL | Hypertonic Saline |
| HSL | Hindustan Steel Limited (India) |
| HSL | Helicopter Anti-Submarine Warfare Squadron Light |
| HSL | Hypermedia Synchronization Language (Digital Research Corporation) |
| HSL | Hue, Saturation, and Luminescence (less common; probably incorrect) |
| HSL | Health Service Laboratory |
| HSL | Helicopter Sling Load (cargo transport) |
| HSL | Home Station Launch |
| HSL | Huntington Station Library (Huntington Station, NY) |
| HSL | Hazard Significant Level |
| HSL | Humane Society of Lewisville, TX |
| HSL | Helvetas Sri Lanka |
| HSL | Hazardous Substance Location (New Zealand HSNO regulations) |