| Acronym | Definition |
|---|
| HSM | High School Musical |
| HSM | High Speed Machining |
| HSM | Hierarchical Storage Management |
| HSM | Hardware Security Module |
| HSM | Hyper Sonic Motor (Sigma lenses) |
| HSM | High Shear Mixer |
| HSM | Health Sciences and Medicine (Australia) |
| HSM | High-Speed Memory |
| HSM | High Speed Module |
| HSM | Host Switching Module |
| HSM | Hot Spare Memory |
| HSM | High Speed Memory |
| HSM | High Speed Mode |
| HSM | High Security Mode |
| HSM | Hierarchical Storage Manager |
| HSM | Homeland Security Management (various organizations) |
| HSM | Hospital de Santa Maria |
| HSM | Host Security Module |
| HSM | Helicopter Maritime Strike |
| HSM | Hot Strip Mill |
| HSM | Humanitarian Service Medal |
| HSM | Heritage Square Museum (Los Angeles, CA) |
| HSM | Hepatosplenomegaly |
| HSM | Housing Services Manager (various locations) |
| HSM | Hikari Sentai Maskman (Super Sentai Series; Japan) |
| HSM | High Speed Modem |
| HSM | Hardware Specific Module |
| HSM | Hunger Solutions Minnesota |
| HSM | Hazardous Substance Management |
| HSM | Hialeah Sound Machine (band) |
| HSM | Helix Security Manager (software) |
| HSM | Heathfield St. Mary (Ascot, Berkshire, England, UK) |
| HSM | Health and Safety Manual |
| HSM | Heat Seeking Missile |
| HSM | Hubble Servicing Mission |
| HSM | HealthSystems of Mississippi |
| HSM | Hospitaller Sisters of Mercy |
| HSM | Hardware to Software Migration (computer programming) |
| HSM | Hull Stress Monitoring |
| HSM | Hospitality Supply Management Forum |
| HSM | Hydraulic Start Motor |
| HSM | Hermetically Sealed Microcircuit |
| HSM | Hierarchical Storage Module |
| HSM | Harmonic Spin Matching |
| HSM | Harmonic Subcarrier Method |
| HSM | Hardened Silo Missile |
| HSM | Headend Service Module |
| HSM | Head-Spine Model (aeromedical research) |
| HSM | Harvard Stanford MIT (top US research universities) |