| Acronym | Definition |
|---|
| HCF | Highest Common Factor (as opposed to lowest common denominator) |
| HCF | Haute Coiffure Francaise (French fashion) |
| HCF | Hardcore Championship Fighting (Mixed Martial Arts) |
| HCF | Highest Common Factor |
| HCF | High Capacity Feeder |
| HCF | Host Controlled Family |
| HCF | Hybrid Crossfire |
| HCF | Hispanic College Fund |
| HCF | Health Care Facilities |
| HCF | High Cycle Fatigue |
| HCF | Health Care Fraud |
| HCF | Hybrid Coordination Function |
| HCF | Hart Communication Foundation |
| HCF | Hutchinson Correctional Facility (Kansas) |
| HCF | Hamilton Community Foundation (Ohio) |
| HCF | High Capacity Feeder (copiers and printers) |
| HCF | Hundred Cubic Feet |
| HCF | Historic Charleston Foundation (South Carolina) |
| HCF | Home Credit Finance |
| HCF | Hospitals Contribution Fund of Australia |
| HCF | Halt and Catch Fire (Hacker's Dictionary) |
| HCF | Health Care Foundation of Greater Kansas City (Kansas City, MO) |
| HCF | Hawai'i Community Foundation |
| HCF | Host Controller Free (modems) |
| HCF | Harbour City Ferries (Sydney, Australia) |
| HCF | Honda Canada Foundation |
| HCF | Host Controlled Family (Rockwell chipset modems) |
| HCF | Half Circle Forward (motion; gaming) |
| HCF | High Cost Fund |
| HCF | Highland Credit Strategies Fund |
| HCF | House Conservatives Fund (Political Action Committee) |
| HCF | Host Command Facility |
| HCF | Heparin Cofactor |
| HCF | Healthy Community Fund (various locations) |
| HCF | Historic Columbia Foundation (Columbia, SC) |
| HCF | Height Correction Factor |
| HCF | Horizon Christian Fellowship |
| HCF | Hardcore Fan |
| HCF | Hybridoma Cloning Factor |
| HCF | Hepatitis C Foundation |
| HCF | Harper Court Foundation |
| HCF | High Carbon Ferrochrome |
| HCF | Hotline Center Foundation |
| HCF | Hot Channel Factor |
| HCF | Hook Content Formula (enumerative combinatorics of Standard Young Tableaux) |
| HCF | Higher Cortical Function |
| HCF | Hardened Compact Fiber |
| HCF | Hardware Configuration Facility |
| HCF | Hard Copy File |
| HCF | Host Computer Facility |
| HCF | Human Care Foundation (New Delhi, India) |