| Acronym | Definition |
|---|
| HCI | Human-Computer Interaction |
| HCI | Hydrochloride |
| HCI | Human Capital Institute |
| HCI | Human Computer Interface |
| HCI | Hyper-Converged Infrastructure (virtual computing) |
| HCI | Hwa Chong Institution (Singapore) |
| HCI | Huntsman Cancer Institute |
| HCI | Health Care Informatics (various organizations) |
| HCI | Health Communications, Inc (publishing) |
| HCI | Health Care Industry |
| HCI | Host Controller Interface |
| HCI | Haut Conseil à l'Integration (French: High Council for Integration; est. 1989) |
| HCI | Health Care International (various locations) |
| HCI | Human Capital Investment |
| HCI | Health Care Improvement |
| HCI | Human Concern International (Ottawa, Ontario, Canada) |
| HCI | Human Computer Interaction |
| HCI | Human Company Integration |
| HCI | Handgun Control, Inc. (est. 1974; formerly National Council to Control Handguns) |
| HCI | Hunt Consolidated, Inc. (Dallas, TX) |
| HCI | Human Capital Index |
| HCI | Healthy Community Initiative (various locations) |
| HCI | Honda Canada, Inc. (cars) |
| HCI | Hot Carrier Injection |
| HCI | Hamilton Center, Inc. (mental health center; Terre Haute, IN) |
| HCI | Home Computing Initiative (UK government DTI) |
| HCI | Health Care Insurer |
| HCI | Harmonised Competitiveness Indicator |
| HCI | Hyperspectral Imaging |
| HCI | Home City Ice (Cincinnati, OH) |
| HCI | Harrison Career Institute |
| HCI | Highly Charged Ion |
| HCI | Hlas Cez Internet (Slovak: Voice over Internet) |
| HCI | Handgun Control, Incorporated |
| HCI | Hotel Corporation of India |
| HCI | Health Care Integrator |
| HCI | Hardware Configuration Item |
| HCI | Home Center Institute |
| HCI | Human Centered Informatics |
| HCI | Hansa Chemie International (Switzerland) |
| HCI | Hardness Critical Item |
| HCI | Human Computer International |
| HCI | Hydrologic Consultants Inc (Lakewood, CO) |
| HCI | Horizon Crossing Indicator |
| HCI | Highly Coercive Interrogation |
| HCI | High Current Interest |
| HCI | Health Care on the Internet (journal) |
| HCI | Hartzog & Crabill Inc. (Tustin, CA traffic and civil engineering) |
| HCI | Host Communications Interface (layer just above the network protocol stack) |
| HCI | Hardware Computer Interface |
| HCI | Harmony Careers International |
| HCI | Healthcare Consultants International (Skokie, IL) |
| HCI | Haveman Computer & Internet |
| HCI | Hanford Capsule Initiative |
| HCI | Huber Consultants International |
| HCI | Horizontal Center of Impact |
| HCI | Horizontal Contracting Integration |
| HCI | Hospitality Consultants, Inc. (Ann Arbor, Michigan) |
| HCI | Horizon Clinicals Infrastructure |