| Acronym | Definition |
|---|
| GPO | Group Policy Object (Microsoft Windows) |
| GPO | Government Printing Office |
| GPO | Group Purchasing Organization |
| GPO | Government Pension Offset |
| GPO | General Post Office |
| GPO | Green Party of Ontario (Ontario, Canada) |
| GPO | Giant Pacific Octopus |
| GPO | Group Policy Object |
| GPO | General Portage Overlay |
| GPO | Garritan Personal Orchestra |
| GPO | Government Project Officer |
| GPO | General Purpose Output |
| GPO | Gas Pipeline Operator |
| GPO | Government Publications Office |
| GPO | Genesis P-Orridge |
| GPO | Greeley Philharmonic Orchestra (Greeley, CO) |
| GPO | General Practitioner in Oncology (Canada) |
| GPO | Guaranteed Purchase Option (insurance) |
| GPO | Good for Parts Only |
| GPO | General Power Outlet (electrical; chiefly Australia) |
| GPO | Geophysical Prove-Out (US Army Corps of Engineers) |
| GPO | Geschäftsprozess Optimierung |
| GPO | General Purpose Outlet (electrical outlet) |
| GPO | Gun Position Officer |
| GPO | GOOS Project Office |
| GPO | Global Process Owner |
| GPO | Gift Planning Officer (various organizations) |
| GPO | Gemeindeparteiobmann (Austria, Europe) |
| GPO | Guam Premium Outlets (Guam USA) |
| GPO | Graphics Processor Option (VT100) |
| GPO | Global Process Outsourcing |
| GPO | Goosepimp Orchestra (band) |
| GPO | Generalized Physical Optics Method |
| GPO | Ground-Based FEL Project Office |
| GPO | Gun Plot Officer |
| GPO | Grade Print Out |