| Acronym | Definition |
|---|
| HUB | Husky Union Building (University of Washington) |
| HUB | Historically Underutilized Business |
| HUB | Hogeschool-Universiteit Brussel (Brussels, Belgium) |
| HUB | Humboldt-Universität zu Berlin (German: Humboldt University Berlin) |
| HUB | Hull University Business (UK) |
| HUB | Hetzel Union Building (Penn State) |
| HUB | Hudson United Bank (New York and New Jersey) |
| HUB | Hydrocarbon-Utilizing Bacteria |
| HUB | Hold Up Battery |
| HUB | HSBC Universal Banking System |
| HUB | Hellenic United Backbone |
| HUB | Harvard University Band |
| HUB | Horizons-Upward Bound |
| HUB | Height Under Boom |
| HUB | Hallam Union Building (Sheffield Hallam University, UK) |