| Acronym | Definition |
|---|
| HCS | Hazard Communication Standard |
| HCS | Heritage Christian School (various locations) |
| HCS | High Content Screening |
| HCS | Health Care Specialist |
| HCS | Headlamp Cleaning System (cars) |
| HCS | Hoover City Schools (Alabama) |
| HCS | Human Capital Strategist (certification; Human Capital Institute) |
| HCS | Hosted Collaboration Solution (Cisco) |
| HCS | Healthcare Consulting Services (Indianapolis, IN) |
| HCS | High Compression Swirl |
| HCS | Home Cinema System |
| HCS | Header Check Sequence |
| HCS | Health Care Strategies (Texas) |
| HCS | Human Capital Solutions |
| HCS | Horticulture and Crop Science (various schools) |
| HCS | Harvard Computer Society |
| HCS | HIV Care Services (Virginia) |
| HCS | Haywood County Schools (North Carolina and Tennessee) |
| HCS | Hippocampal Sclerosis (neurology) |
| HCS | Hard Clad Silica (optical fiber) |
| HCS | High Carbon Steel |
| HCS | Humane Cosmetics Standard |
| HCS | Healthcare Software (Australia) |
| HCS | Housing/Community Services (various locations) |
| HCS | Human Chorionic Somatomammotropin |
| HCS | Human Capital Strategy |
| HCS | Head of Customer Services (various locations) |
| HCS | Homewood City Schools (Homewood, AL) |
| HCS | House Condition Survey (UK) |
| HCS | Hazardous Chemical Storage (regulations) |
| HCS | Highway Capacity Software |
| HCS | Hierarchical Cell Structure |
| HCS | Header Check Sequence (DOCSIS specification) |
| HCS | Hull Collegiate School (Anlaby, England, UK) |
| HCS | Hospital Central Service (various organizations) |
| HCS | Hot Club Sandwich (band) |
| HCS | Histochemical Society |
| HCS | Host Computer System |
| HCS | Hertford Choral Society (Hertfordshire, England, UK) |
| HCS | Hard Core Sledder (online forum) |
| HCS | Header Checksum |
| HCS | Hollywood Casino Shreveport |
| HCS | Horizon Casualty Services (New Jersey) |
| HCS | Holland Construction Services (Swansea, IL) |
| HCS | Helicopter Combat Support (Special) Squadron (US Navy) |
| HCS | Hospital & Healthcare Compensation Service |
| HCS | High Current System |
| HCS | Hajdu-Cheney Syndrome |
| HCS | Halifax Consciousness Scanner (neuroimaging) |
| HCS | Halley's Comet Software |
| HCS | Harry C. Stutz (automobile developer) |
| HCS | HIH Claims Support (insurance; Australia) |
| HCS | Habesha Capital Services (Ethiopia) |
| HCS | HUMINT Control System |
| HCS | Human Control Strategy (robotics) |
| HCS | HES Cabling Systems (Turkey) |
| HCS | Hundred Call Seconds |
| HCS | Habermehl Consulting Services (Cincinnati, OH) |
| HCS | Human Chorionic Somatotropin |
| HCS | Hub City Stompers (New Brunswick, NJ band) |
| HCS | Hokkaido Computer School (Japan) |
| HCS | Helicopter Coordination Section |
| HCS | Housing Counseling Services, Inc (Washington, DC) |
| HCS | Holland Christian Schools |
| HCS | Holderness Central School (New Hampshire) |
| HCS | HardCore Supervisor (Multics) |
| HCS | Home and Community-Based Service Program |
| HCS | House Connection Sewer |
| HCS | High-Performance Computing and Simulation Research Laboratory |
| HCS | Humanitarian Common Service |
| HCS | Hardcore Style (music) |
| HCS | Helicopter Control Ship |
| HCS | Health Care Secretary |
| HCS | Harrogate Choral Society (UK) |
| HCS | Hydrogen Chloride Scrubber |
| HCS | Health Card Server |
| HCS | Hybrid Computation and Simulation |
| HCS | Healthy Communities Scholars (Brown University; Providence, RI) |
| HCS | Haptic Characteristic Structures |
| HCS | High Class Society |
| HCS | Holy Cross Seminary (various locations) |
| HCS | Healthcare Compensation Solutions (Prattville, AL) |
| HCS | HAF Computer System |
| HCS | Hydrogen Containing Solvent |
| HCS | Haven City Stories (online RPG) |
| HCS | Human Complex System (social science) |
| HCS | Hutchinson Computer Systems Ltd (UK) |
| HCS | Human Communications Science |