| Acronym | Definition |
|---|
| GPU | Graphics Processing Unit |
| GPU | Ground Power Unit |
| GPU | General Public Utilities |
| GPU | Green Party of Utah |
| GPU | Gas Piston Upper (Addax, Inc.) |
| GPU | General Purpose User |
| GPU | General Postal Union (1847-1879, now UPU Universal Postal Union) |
| GPU | Global Pastry Uprising |
| GPU | General Processor Unit |
| GPU | Graphics Processing/Processor Unit |
| GPU | Ground Processing Unit |
| GPU | Germ Plasm Utilization (livestock) |
| GPU | Genomics Policy Research Unit |
| GPU | Garment Production Unit (garment flammability testing) |
| GPU | Group Personnel Unit (UK) |
| GPU | Gossudarstwenoje Polititscheskoje Upravlenije (Russian: National Political Administration; Soviet Secret Service until 1937) |
| GPU | Gas Particulate Unit (used in chemical warfare agent filters) |
| GPU | Gossudarstwennoje Prawowoje Uprawlenije (Russian: National Legal Administration) |
| GPU | Groupe Permanent Chargé des Installations Nucléaires de Base (French: Standing Group of Base Nuclear Installations) |