| Acronym | Definition |
|---|
| HSE | House |
| HSE | Health and Safety Executive |
| HSE | Health Service Executive (Ireland) |
| HSE | Higher School of Economics (Moscow, Russia) |
| HSE | Higher Secondary Education |
| HSE | Hamilton Southeastern (High School) |
| HSE | Health, Safety & Environment |
| HSE | High Self Esteem |
| HSE | Herpes Simplex Encephalitis (disease) |
| HSE | Helsinki School of Economics |
| HSE | Highly Siderophile Elements (geochemistry) |
| HSE | Home Shopping Europe |
| HSE | High Speed Ethernet (Fieldbus Foundation) |
| HSE | Helsinki Stock Exchange (Finland) |
| HSE | Hd Service Encoder |
| HSE | High Speed Encryption |
| HSE | Hosting Solution Engine |
| HSE | Horizontal Size Extension |
| HSE | High Speed Ethernet |
| HSE | Hyper Streaming Engine |
| HSE | Health Survey for England (National Health Service; UK) |
| HSE | Health Sciences East (University of California, San Francisco) |
| HSE | Hygiène, Sécurité et Environnement (France) |
| HSE | Home Shopping Experience (New Hampshire) |
| HSE | High School Extended |
| HSE | Heat Shock Response Element (biochemistry) |
| HSE | High Speed Edition |
| HSE | Hosting Solution Engine (Cisco) |
| HSE | Billy Mitchell Airport (Hatteras-Buxton, North Carolina) |
| HSE | Health & Safety Executive Officer |
| HSE | High-Speed Excavator |
| HSE | Human Software Engineering |
| HSE | Hic Sepultus (or Situs) Est (Latin: Here Is Buried (or Laid)) |
| HSE | Hyperbaric Support Equipment |
| HSE | Harmonic State Estimation |
| HSE | How Strangely Erotic |
| HSE | Heater, Steam-Electric |
| HSE | Hand-Shaking Expansion |