| Acronym | Definition |
|---|
| HSF | Hispanic Scholarship Fund |
| HSF | Human Space Flight |
| HSF | Heat Shock Factor |
| HSF | HeatSink and Fan |
| HSF | Home Service Force |
| HSF | Hot Spot Finder |
| HSF | Heat Sink and Fan |
| HSF | Have Some Fun |
| HSF | Heart and Stroke Foundation of Canada (Fondation des maladies du coeur du Canada) |
| HSF | Hyperion Strategic Finance (software) |
| HSF | Heat Sink Fan (CPU cooling) |
| HSF | Hospital Saturday Fund (UK and Ireland) |
| HSF | Health Sciences Faculty (various locations) |
| HSF | Hazardous Substance Free |
| HSF | Historic Salisbury Foundation (Salisbury, NC) |
| HSF | Healthy San Francisco (city-sponsored initiative; California) |
| HSF | Hawaii Shakespeare Festival |
| HSF | Horizontal Scanning Frequency (computer graphics) |
| HSF | Historic Savannah Foundation |
| HSF | Heart Surgery Forum |
| HSF | Hot Stamping Foil |
| HSF | High Sierra Format |
| HSF | Home School Foundation |
| HSF | Heated Square Feet |
| HSF | Hôpital Sans Frontière |
| HSF | Health Status Form |
| HSF | Hunger Strike Force |
| HSF | Humber Student' Federation (Canada) |
| HSF | Homeland Security Foundation |
| HSF | Hindu Students Forum (UK) |
| HSF | Hepatocyte Stimulatory Factor |
| HSF | Han Shot First (Star Wars fan-base and wiki) |
| HSF | Hotel San Francesco (Italy) |
| HSF | Hyper Sentinel Force (Street Fighter game) |
| HSF | Health, Safety, and Fire |
| HSF | Huffman-Shannon-Fano (coding scheme) |
| HSF | Hawaiian Sea Frontier |
| HSF | Hot Springs Fault (California quake fault) |
| HSF | Hiller-Sucher-Feinberg |
| HSF | Hotel Service Fee (charged at luxury resorts for extra services) |
| HSF | Hartford Seminary Foundation |
| HSF | Hyper-Sonic Flow |
| HSF | Head Steerable FLIR |
| HSF | Heat Stable Function |
| HSF | High Safety Factor |
| HSF | Hot Section Factor |
| HSF | Humanitas Salubritas et Felicitas (former Humanitarian Aid Organization, Germany) |
| HSF | Higher Standard Flags |
| HSF | Household Surveys Facilities |