| Acronym | Definition |
|---|
| HPU | Harry Potter Universe (online roleplay) |
| HPU | Hawaii Pacific University |
| HPU | High Point University |
| HPU | High Performance Unload (IBM) |
| HPU | Hydraulic Power Unit |
| HPU | Howard Payne University (Brownwood, TX) |
| HPU | Handheld Programming Unit |
| HPU | High Power Unit |
| HPU | Himachal Pradesh University (India) |
| HPU | High Pressure Unit (various companies) |
| HPU | Health Protection Unit (UK) |
| HPU | Hewlett Packard University (various locations) |
| HPU | Hebei Polytechnic University (Hebei, China) |
| HPU | Homeless Persons Unit (UK) |
| HPU | Hydraulic Pumping Unit |
| HPU | Heat Pump Unit |
| HPU | Hydrogen Production Unit |
| HPU | Haemopyrrollactamuria (vitamin deficiency) |
| HPU | Has Passed Urine |
| HPU | High Priority Unit |
| HPU | Hydrothermal Processing Unit |
| HPU | Hull Processing Unit (Bradley Fighting Vehicle A3) |
| HPU | Hour Per Unit |