| Acronym | Definition |
|---|
| H2H | Head to Head |
| H2H | Happy to Help (also seen as HTH) |
| H2H | Highway to Hell |
| H2H | Heart to Heart |
| H2H | Hard to Handle |
| H2H | Hand to Hand (combat) |
| H2H | Human to Human (transmission of disease) |
| H2H | Human to Human (information technology, business process management) |
| H2H | Hanoi to Ho Chi Minh City (Vietnam) |
| H2H | Host to Host |
| H2H | Head to Hollywood (brain tumor survivor organization) |
| H2H | Here to help |
| H2H | Halfway to Hazard (band) |
| H2H | Heroes to Hired (military civilian job transition) |
| H2H | Haney to Harrison (Vancouver, BC, Canada race) |
| H2H | House 2 Home (various organizations) |
| H2H | Helmet2Helmet (NFL forum) |
| H2H | Hero to Hero (troop morale campaign) |
| H2H | Him to Her |
| H2H | Hummer 2 Hydrogen (GM experimental hydrogen fuel cell-powered SUV) |
| H2H | Hazardous 2 Health (gaming) |