| Acronym | Definition |
|---|
| GU | Guam (US postal abbreviation) |
| GU | Global Underground (music label) |
| GU | Georgetown University |
| GU | Griffith University (Australia) |
| GU | Gonzaga University |
| GU | Göteborgs Universitet (University of Gothenburg, Sweden.) |
| GU | Grow Up |
| GU | Guildford (postcode, United Kingdom) |
| GU | Genitourinary |
| GU | Gallaudet University |
| GU | Gastric Ulcer |
| GU | Glasgow University (Glasgow, Scotland, UK) |
| GU | Graceland University (Iowa) |
| GU | Gannon University (Pennsylvania) |
| GU | Generalunternehmer (German) |
| GU | Gujarat University (India) |
| GU | Gently Used |
| GU | General User |
| GU | Grace University (Omaha, Nebraska) |
| GU | Gunma University (Japan) |
| GU | Gazi University (Turkey) |
| GU | Gaming Universe |
| GU | Gomal University (Deraismailkhan, Pakistan) |
| GU | Guilan University (Iran) |
| GU | Geographical Unit (currency) |
| GU | Geographically Undesirable (partner too far away to date on a regular basis) |
| GU | Gastroenterology/Urology |
| GU | Geometrically Uniform |
| GU | Guidance Unit |
| GU | Guerilla Unit (gaming group) |
| GU | Global Uranium Corporation (Toronto, ON, Canada) |
| GU | Geschützte Ursprungsbezeichnung (German: Protected Designation of Origin) |
| GU | Gaming Union (gaming) |
| GU | Gaming Update (forum) |
| GU | Gamer Unlimited (forum) |
| GU | Gateway Utopia (gaming) |
| GU | Grafton and Upton Railroad Company |
| GU | Games Unleashed (online gaming community) |
| GU | Gamesunderground (gaming) |