| Acronym | Definition |
|---|
| HSSM | High Speed Switch Module |
| HSSM | Humane Society of South Mississippi (Gulfport, MS) |
| HSSM | Hydrocarbon Spill Screening Model (US EPA) |
| HSSM | HiCommand Storage Services Manager (Hitachi) |
| HSSM | Highway Security Sensitive Materials (Transportation Security Administration; US DHS) |
| HSSM | Hierarchical Software State Machine |
| HSSM | horse serum-supplemented medium |
| HSSM | Humane Society of Southwestern Michigan (Benton Harbor, MI) |
| HSSM | High School Sports Magazine (website) |
| HSSM | High School Sports Media |
| HSSM | Hon Sui Sen Memorial (Singapore) |
| HSSM | High Speed Scanning Module (Knowledgeone Corporation) |
| HSSM | Hard Sector State Machine |
| HSSM | Health and Social Services Managers |
| HSSM | High Spindle Speed Machining |
| HSSM | High Speed Standoff Missile |
| HSSM | High Speed Spindle Motor |
| HSSM | Historical and Scientific Society of Manitoba (Canada) |
| HSSM | Harris Solid State Malaysia |
| HSSM | High School of Sports Management (Brooklyn, NY) |
| HSSM | Hierarchical Simultaneous Set Membership |
| HSSM | Hot Stove Saturday Morning |
| HSSM | High School Science & Mathematics Faculty Program (United States Army) |
| HSSM | Hidden State Shape Model |
| HSSM | High School Student Ministry |
| HSSM | Highway System Status Maps (state of Georgia) |
| HSSM | Hunter Specialty Steel Mill (project) |
| HSSM | Humanities, Social Science and Management |
| HSSM | Hotel and Support Services Manager |
| HSSM | Head Start St Maries |
| HSSM | Hansen Stahl Sales and Marketing |
| HSSM | Human Systems Strategic Management (East Lansing, MI) |
| HSSM | Hardened Space Sensor Model (US NASA) |
| HSSM | Health System Simulation Modelling |
| HSSM | Harris Semiconductor Sector - Mountaintop |
| HSSM | High Speed Sorting Machine (US Postal Service) |
| HSSM | Hitachi Storage Service Manager |
| HSSM | Hicks-Slutsky Substitution Matrix |
| HSSM | Housing Superannuation Spreadsheet Model (Australia) |