| Acronym | Definition |
|---|
| HSU | Humboldt State University (aka California State University, Humboldt) |
| HSU | Hardin-Simmons University (Abilene, Texas) |
| HSU | Henderson State University (Arkansas) |
| HSU | Heroes of the Soviet Union |
| HSU | Helmut Schmidt University (Hamburg, Germany; est. 1973) |
| HSU | High Speed Usb |
| HSU | Hrvatska Stranka Umirovljenika (Croatian Pensioner Party, political party) |
| HSU | Huachiew Chalermprakiet University (Thailand) |
| HSU | Happy Science University (Japan) |
| HSU | Health and Safety Unit (various locations) |
| HSU | Hartridge Smoke Unit (exhaust gas measurement) |
| HSU | High Speed Unit |
| HSU | Hyper Static Union (band) |
| HSU | Humane Society of Utah |
| HSU | Helium Service Unit |
| HSU | Hybrid Switch Unit |
| HSU | Heroh Sports University |
| HSU | Horizontal Space Utilization (efficiency metric) |