HLCS
| Acronym | Definition |
|---|---|
| HLCS | Holocarboxylase Synthetase |
| HLCS | Half-Life: Counter-Strike (retail Counter Strike) |
| HLCS | Horned Lizard Conservation Society |
| HLCS | Houghton Lake Community Schools (Michigan) |
| HLCS | Hyde Leadership Charter School (est. 2006; Bronx, New York, NY) |
| HLCS | Harpoon Launch Control System |