| Acronym | Definition |
|---|
| HDE | Humanitarian Device Exemption |
| HDE | Hybrid Diesel-Electric |
| HDE | Hauptverband des Deutschen Einzelhandels (Central Association of German Retail Trade) |
| HDE | High Definition Encoder (various companies) |
| HDE | Help Desk Essentials (certification) |
| HDE | Hybrid Detection Engine |
| HDE | High Definition Encoder |
| HDE | Horizon Digital Enterprise, Inc. (Japan) |
| HDE | Heavy-Duty Engine |
| HDE | Higher Diploma in Education (UK) |
| HDE | Heroldo de Esperanto (Esperanto: Esperanto Herald; magazine; est. 1920) |
| HDE | Home Decor Exchange |
| HDE | Holdrege, Nebraska (airport code) |
| HDE | Héroes de la Educación (Spanish: Heroes of Education; Guatemala) |
| HDE | Hottest Deals Ever (Allentown, PA) |
| HDE | Hypertext Document Engineering |
| HDE | Heater Drive Electronics |
| HDE | Home Docking Environment |
| HDE | Historical Data Entry |
| HDE | Highly Distributed Environment |
| HDE | Hacking Defined Experts (course) |
| HDE | Number of Honeydew Elements |