| Acronym | Definition |
|---|
| HDF | Hierarchical Data Format |
| HDF | Hubble Deep Field |
| HDF | Home Depot Foundation (est. 2002) |
| HDF | Holland Dance Festival (est. 1987) |
| HDF | Human Development Foundation (Schaumburg, IL) |
| HDF | Host Data Facility |
| HDF | Help Development File |
| HDF | Hdsl Dual Framer |
| HDF | Hand Dyed Fibers |
| HDF | Heavy Duty Fabric (product feature) |
| HDF | High Density Fibreboard |
| HDF | Hydrofinishing |
| HDF | Hereditary Disease Foundation |
| HDF | Hastings Diversified Utilities Fund (also seen as HDUF; Australia) |
| HDF | Haemodiafiltration |
| HDF | Hard Drive File (computing) |
| HDF | Human Diploid Fibroblast (oncology) |
| HDF | Halt Die Fresse (German) |
| HDF | High-frequency Direction Finding |
| HDF | Hard Decision Feedback |
| HDF | Highest Density First |
| HDF | Hungarian Defense Force |
| HDF | Hard Disk Failure |
| HDF | Halogenated Dibenzofuran |
| HDF | High Density Frame (Seicor) |
| HDF | Halt Dich Fest (Germany) |
| HDF | Hikkaduwa Development Foundation (Sri Lanka) |