| Acronym | Definition |
|---|
| HDL | High Density Lipoprotein (so-called "good" cholesterol) |
| HDL | Hardware Description Language |
| HDL | Handle |
| HDL | Hab Dich Lieb |
| HDL | Heavy-Duty Liquid (detergent) |
| HDL | Header Data Length |
| HDL | Hp Description Language |
| HDL | Heavy Duty Long |
| HDL | Hardware Design Language |
| HDL | Harry Diamond Laboratories (US Army Research Laboratory) |
| HDL | Hundred Dollar Laptop (One Laptop per Child program) |
| HDL | Honey-Do List |
| HDL | Huey, Dewey and Louie |
| HDL | Human Development and Learning (various schools) |
| HDL | Hope Dies Last (band) |
| HDL | Hierarchical Design Language |
| HDL | Hospital Distrital de Lamego (Portugal) |
| HDL | Hypothesis Driven Lexical Adaptation |
| HDL | Holding Design Load |