| Acronym | Definition |
|---|
| HC | Health Care |
| HC | Health Canada |
| HC | Hippocampus |
| HC | High-Capacity |
| HC | High Court |
| HC | Hockey Canada (formerly Canadian Hockey Association) |
| HC | High Capacity |
| HC | Hepatitis C (disease) |
| HC | Health Center |
| HC | Holy Cross (College of the Holy Cross in Worcester, Massachusetts) |
| HC | Hard Cover |
| HC | Hard Core |
| HC | Homecoming |
| HC | House of Commons |
| HC | Health Check |
| HC | Headcanon |
| HC | Hydrocarbon |
| HC | High Confidence |
| HC | History Channel (TV) |
| HC | Housing Corporation (various organizations) |
| HC | Holy Crap |
| HC | Habeas Corpus |
| HC | Hard Copy |
| HC | Hospital Corpsman (US Navy) |
| HC | Hair Cuttery |
| HC | Hydrocortisone Cream |
| HC | Home Country |
| HC | Hunting Club (various locations) |
| HC | Homebrew Channel (Wii applications) |
| HC | Chaplain (USAF) |
| HC | Heart Catheterization (cardiology) |
| HC | Host Country |
| HC | Honors College |
| HC | Huntingdon College (Montgomery, Alabama) |
| HC | Holy Cow |
| HC | Host Controller (USB device) |
| HC | Honoris Causa |
| HC | Hot Coffee |
| HC | Headcount |
| HC | Heart Chakra |
| HC | Healthy Control |
| HC | Health Claims (insurance) |
| HC | Hydrogen Chloride |
| HC | Happy Christmas |
| HC | Humidity Control |
| HC | History of the Church (Joseph Smith) |
| HC | Head Circumference |
| HC | Healthy Cooking |
| HC | Hybrid Computer |
| HC | High Council (LDS church) |
| HC | HospitalityClub |
| HC | Humanitarian Coordinator |
| HC | Head Cold |
| HC | Human-Centered |
| HC | Habbo Club (chat site) |
| HC | High-Speed CMOS (family of logic integrated circuits) |
| HC | Hazard Control (NIOSH) |
| HC | Honor Code |
| HC | Honey Comb |
| HC | Hitachi Capital (Japan) |
| HC | Haverford College |
| HC | Horizontal Clearance |
| HC | Hypercard |
| HC | Home Church |
| HC | Hitman: Contracts (video game) |
| HC | Happy Couple |
| HC | Hampshire College |
| HC | Hors Concours (French: out of the competition; a participant ineligable to win prizes) |
| HC | Hand Control |
| HC | Hulchul (Pakistan forum) |
| HC | Household Component |
| HC | Huntington's Chorea (hereditary progressive neurodegenerative disorder) |
| HC | Hwa Chong |
| HC | Hydraulic Conductivity |
| HC | Hillsdale College (Hillsdale, Michigan) |
| HC | High Cube (shipping container) |
| HC | Helicopter Combat Support Squadron |
| HC | Hague Convention |
| HC | Hope College (Holland, MI, USA) |
| HC | Head Constable |
| HC | Housing Credit |
| HC | How Cute |
| HC | Humanitarian Community |
| HC | Huffman Code (coding scheme) |
| HC | Holden Caulfield |
| HC | Hope Center (various organizations) |
| HC | Hog Cholera (classical swine fever) |
| HC | Hanging Chad |
| HC | Historical Cost (accounting) |
| HC | Heritage Christian (High School) |
| HC | Howard Carter |
| HC | Handling Capacity |
| HC | Historical Committee |
| HC | Heating Coil |
| HC | Hospital Council |
| HC | Hazardous Cargo |
| HC | Highway Contract (rural route post office addressing) |
| HC | High Concentrate |
| HC | Herding Champion (AKC) |
| HC | Heating Contractor |
| HC | Hogwarts Castle (Harry Potter) |
| HC | Heavy Clouds |
| HC | Helicopter Command |
| HC | Haley's Comet |
| HC | High Containment (biological hazard laboratories) |
| HC | Hazard Category |
| HC | Hattie Carnegie (fashion designer) |
| HC | Hiwassee College (Madisonville, TN) |
| HC | Horizontal Control Line |
| HC | Heat Conservation (piping engineer) |
| HC | Hybrid Coordinator |
| HC | Hampton Classic (horse show) |
| HC | Housekeeping Channel (website) |
| HC | Head Cashier |
| HC | Hoofdconducteur (guard on Dutch train) |
| HC | Hazardous Constituent |
| HC | Hexachloroethane-Zinc (white smoke grenade) |
| HC | Hero Camp |
| HC | High Coupling |
| HC | Human Click |
| HC | Handicap/Handicapped |
| HC | Hand Cancel |
| HC | Hand Cannon |
| HC | Handicapable |
| HC | Hearing Concern |
| HC | Hors d' Commerce (French: not for trade) |
| HC | Horizontally Challenged |
| HC | Host Comparison |
| HC | Helicopter, Cargo (military aircraft designation) |
| HC | Headquarters Chaplain (US DoD) |
| HC | High Charity (gaming) |
| HC | Holland Christian High School (Michigan) |
| HC | Hemolytic Complement Activity (immunology) |
| HC | Hard Computing |
| HC | Helena Chronicles (Star Trek internet-based fanfilm) |
| HC | Helicopter Coordinator |
| HC | Handoff Call |
| HC | Hairdressing Council (UK) |
| HC | Hazardous Code |
| HC | Horizontal Cutter |
| HC | Hoffmantown Church (Albuquerque, NM) |
| HC | Harmonic Coding |
| HC | Microsoft Windows Help Compiler |
| HC | Hexachlorothannol |
| HC | Hannibal Connecting Railroad |
| HC | Hyperbolic Congruence |
| HC | Head Chainman (surveyors) |
| HC | Hendrickson Consulting (Los Alamos, NM) |
| HC | Hasp and Clasp |
| HC | Hover College (Ontario, Canada) |
| HC | Hexachlorethane Mix (US Navy) |
| HC | Heston College (Hesston, KS) |
| HC | Household Claims Screen |
| HC | Headway Controller |