| Acronym | Definition |
|---|
| HSSC | Higher Secondary School Certificate |
| HSSC | Health Sciences South Carolina (est. 2004) |
| HSSC | Harris-Stowe State College (St.Louis, MO) |
| HSSC | Health and Social Services Committee (various organizations) |
| HSSC | Health and Social Services Center (New Mexico) |
| HSSC | High School Science Club (Houston, TX) |
| HSSC | High Sierra Sport Company (Gurnee, IL) |
| HSSC | High Speed Subcarrier Committee (National Radio Systems Committee) |
| HSSC | Harmonised System of Survey and Certification |
| HSSC | High Street Supply Chain |
| HSSC | Hennepin South Services Collaborative (Minnesota) |
| HSSC | Heating, Sweating, Spontaneous Combustion (insurance) |
| HSSC | Hawaii State Student Council |
| HSSC | Human Services Standing Committee (Australia) |
| HSSC | High-Speed Serial Communication |
| HSSC | High School Summer College (Stanford University) |