| Acronym | Definition |
|---|
| HOT | Hotel |
| HOT | Heart Of Texas |
| HOT | Hands-On Training |
| HOT | High Occupancy Toll (transportation) |
| HOT | Higher Order Thinking (school system) |
| HOT | Hawaii Ocean Time-Series |
| HOT | HUP (Hirschman Uncertainty Principle) Optimal Transform |
| HOT | Herald of Truth (ministry) |
| HOT | Help Our Troops |
| HOT | Handels-Onderneming Telgenkamp (Dutch game seller) |
| HOT | House of Thule (gaming; EverQuest) |
| HOT | Hyperbaric Oxygen Therapy |
| HOT | Higher Order Term (mathematics) |
| HOT | Helping Our Teachers (various schools) |
| HOT | Heal Over Time (gaming) |
| HOT | Hematology, Oncology and Transplantation (Minnesota) |
| HOT | Hypertension Optimal Treatment |
| HOT | Heating Oil Tank |
| HOT | High Output Turbo |
| HOT | High Output Technology |
| HOT | Home Test |
| HOT | Higher Order and Typed |
| HOT | Hero of Time (gaming) |
| HOT | Herd of Turtles |
| HOT | House of Tools |
| HOT | Health Outreach Team |
| HOT | High-Five of Teenagers (band) |
| HOT | Hawaiian Ocean Time |
| HOT | House Of Toast |
| HOT | Home of Tomorrow |
| HOT | Highly Optimized Tolerance |
| HOT | Home Ownership Team |
| HOT | Horizontal Output Transistor |
| HOT | High Output Turbo (Saab) |
| HOT | Heap Only Tuple (computing) |
| HOT | Home Order Television |
| HOT | Herd of Thunder (marching band; University of South Florida;Tampa, FL) |
| HOT | Home and Office Technology (Atlanta, GA) |
| HOT | House of Trust (song) |
| HOT | Hat-On-Tight (jailer's term for arrestee about to be released) |
| HOT | Hot Springs, AR, USA - Memorial Field (Airport Code) |
| HOT | Head of Terms |
| HOT | Heroine of Time |
| HOT | Hits on Track (high energy physics) |
| HOT | Hall of Testing (Everquest, gaming) |
| HOT | Height Over Terrain |
| HOT | Hierarchical Octet Tree (computer science) |
| HOT | Health-Oriented Telecommunications |
| HOT | Holographic One-Tube |
| HOT | Hot Oil Traced |