| Acronym | Definition |
|---|
| HFE | Hemochromatosis |
| HFE | Human Factors Engineering |
| HFE | Hardware Forwarding Engine |
| HFE | Hidden Field Equations |
| HFE | Herschend Family Entertainment Corporation (theme parks; Norcross, GA) |
| HFE | Hydrofluoroether (cleaning solvent) |
| HFE | Heavy Fuel Engine (unmanned aerial vehicles) |
| HFE | Human Factors in Electronics |
| HFE | High Frequency Engineering |
| HFE | Hartree Fock Exchange (physics; chemistry) |
| HFE | Hope For Europe |
| HFE | Horizontal Fiscal Equalisation |
| HFE | High Frequency Executive |
| HFE | Heat Flow Experiment |
| HFE | Forward Current Gain |
| HFE | Human Failure Event |
| HFE | Helmholtz Free Energy |
| HFE | Hardware Forwarding Engine (Cisco) |
| HFE | High Fuel Economy |
| HFE | Heavy Front Engine |
| HFE | Handicap FormEduc (Louga, Senegal) |