| Acronym | Definition |
|---|
| HLR | Home Location Register (register component that interfaces with other components in a GSM and CDMA system) |
| HLR | Harvard Law Review |
| HLR | Home Location Register |
| HLR | Half-Life Rally (gaming, Half-Life modification) |
| HLR | Hidden Line Removal (CAD) |
| HLR | Heavy Lift Replacement (USMC replacement aircraft) |
| HLR | High Level Requirement |
| HLR | Hoffman La Roche |
| HLR | Heart-Lung Resuscitator |
| HLR | Historic Lotus Register |
| HLR | Human Language Resources |
| HLR | High Level Reservoir |
| HLR | High Level Rescue |
| HLR | Higher Level Reviewer (US DoD) |
| HLR | Horizontal Recirculator (industrial refrigeration) |
| HLR | Hustle Loyalty Respect |
| HLR | Honorary Local Representative |
| HLR | High Lift Rotor |
| HLR | Hobbes, Locke & Rousseau |