| Acronym | Definition |
|---|
| IRL | Indy Racing League |
| IRL | Ireland |
| IRL | In Real Life |
| IRL | Republic Of Ireland (Eireann, International Auto Identification) |
| IRL | Indian River Lagoon |
| IRL | Institut Ramon Llull (Catalan studies consortium; various locations) |
| IRL | Industrial Research Limited (New Zealand) |
| IRL | Instructional Reading Level (education) |
| IRL | Inter Repeater Link |
| IRL | Immunohematology Reference Laboratory (various organizations) |
| IRL | Industrial Research Ltd (New Zealand Crown Research Institute) |
| IRL | Interrupt Request Line (computing) |
| IRL | Inter-Repeater Link |
| IRL | Im Richtigen Leben (German: In real life) |
| IRL | Industrial Robot Language |
| IRL | Interactive Reader Language |
| IRL | Injured Reserve List (football) |
| IRL | Information Resources Ltd. |
| IRL | Integrated Regional Laboratories (Ft Lauderdale, Florida) |
| IRL | Infinite Rocket Launcher (Resident Evil 4 game) |
| IRL | Internet Reconfigurable Logic |
| IRL | Information Retrieval Language |
| IRL | International Refugee Law |
| IRL | Intelligent Robotics Laboratory (School of Engineering, Vanderbilt University) |
| IRL | Inspiratory Resistive Loading (respiratory studies) |
| IRL | Incandescent Reflector Lamp (lighting) |
| IRL | Integrated Reader Lock |
| IRL | Institute for Research in Learning |
| IRL | Information Resource Locator |
| IRL | Improvised Rocket Launcher (insurgency) |
| IRL | Integrated Requirements List (US Air Force) |
| IRL | Information-Based Remaining Lifetime |
| IRL | Interagency Review Letter |