| Acronym | Definition |
|---|
| ISL | Island |
| ISL | Iceland (ISO Country code) |
| ISL | IBM (International Business Machines Corporation) Software Labs |
| ISL | Islamabad (Pakistan) |
| ISL | Independent School League |
| ISL | Inter-Switch Link (Cisco) |
| ISL | Indoor Soccer League (various locations) |
| ISL | Institute of Shipping Economics and Logistics |
| ISL | Investment Services Limited |
| ISL | Illinois State Library |
| ISL | Intelligent Systems Laboratory |
| ISL | Indian Sign Language |
| ISL | International Sign Language (auxiliary language) |
| ISL | Impact on Student Learning (various organizations) |
| ISL | Information Systems Limited (various locations) |
| ISL | International Student Life (various schools) |
| ISL | Information Systems Laboratory |
| ISL | Inter Subnetwork Link |
| ISL | Inter Switch Link |
| ISL | Industry Solutions Labs |
| ISL | Inter Satellite Link |
| ISL | Intermediate Silicon Layer |
| ISL | Internal Systems Limited |
| ISL | Integrated Service-Learning (various schools) |
| ISL | In-Situ Leaching (Uranium mining) |
| ISL | Initial System Loader |
| ISL | Information Solutions Ltd. (various locations) |
| ISL | India Software Lab (IBM) |
| ISL | Island Soccer League (Bermuda) |
| ISL | Inverse Square Law (physics) |
| ISL | French-German Research Institute Saint Louis |
| ISL | Intersatellite Link |
| ISL | Inertial Systems Laboratory (US NASA) |
| ISL | Integrated Systems Laboratory |
| ISL | International School of Lausanne (Lausanne, Switzerland) |
| ISL | Interactive System Language |
| ISL | Industrial Security Letter |
| ISL | Information Security Laboratory (various locations) |
| ISL | International School of Luxembourg |
| ISL | Industry Solutions Lab (IBM) |
| ISL | Internet Solutions Limited (Canada) |
| ISL | Institute of State and Law |
| ISL | Involuntary Stress Leave |
| ISL | Integrated Stop Loss (insurance) |
| ISL | Intermediate Silicon Layers |
| ISL | Individual Stop Loss (insurance industry) |
| ISL | Integrated Schottky Logic |
| ISL | Indeterminate Sentence Law (California) |
| ISL | Integrated Sidelobe Level |
| ISL | In Silico Liver |
| ISL | Installation Sequence List |
| ISL | Inside Skin Line |
| ISL | Industrial Safety Legislation |
| ISL | Initial/Integrated Stock List |
| ISL | Intersite Link |
| ISL | Item Study Listings |
| ISL | Inbucon Services, Ltd. (Canada) |
| ISL | IMO ShortList (International Mathematical Olympiad) |
| ISL | Isospin Facility |
| ISL | Integrated Services Lab (Sprint - Ion Lab) |
| ISL | Inter-Shelter LAN |
| ISL | Ice Strengthened Lifeboat |
| ISL | Integral Senior Living, LLC (senior care residential facilities; Carlsbad, CA) |