| Acronym | Definition |
|---|
| IRSA | Interest Rate Swap Agreement (financial instrument) |
| IRSA | Ibm Rational Software Architect |
| IRSA | Indus River System Authority |
| IRSA | International Rett Syndrome Association |
| IRSA | Istituto di Ricerca Sulle Acque (Italian: Water Research Institute) |
| IRSA | Indonesia Regional Science Association |
| IRSA | Interest Rate Sensitive Asset |
| IRSA | International Rural Sociology Association |
| IRSA | International Radiosurgery Support Association |
| IRSA | Intramural Recreational Sports Association (various locations) |
| IRSA | Irish Research Staff Association (est. 2007) |
| IRSA | Institute of Remote Sensing Application (China) |
| IRSA | Lackfabrik Irmgard Sallinger GmbH (Deisenhausen, Germany) |
| IRSA | Infrared Science Archives |
| IRSA | Institution Régionale des Sourds et des Aveugles (French: Regional Institution for the Deaf and Blind) |
| IRSA | Institut Royal des Sourds et Aveugles (Brussels school for deaf & blind) |
| IRSA | Istituto Per Le Ricerche Di Storia Dell'arte (Italian: International Institute for Art Historical Research) |
| IRSA | International Road Safety Academy Association (Netherlands; est. 2004) |
| IRSA | International Retained Search Associates (employment recruiting; Mount Pleasant, SC) |
| IRSA | Independent Railway Supervisors Association |
| IRSA | Invercargill Returned Services' Association, Inc. (Southland, New Zealand, affiliated with Royal New Zealand Returned Services' Association Inc.) |