| Acronym | Definition |
|---|
| IRSL | Instituto Real de San Luis (Spanish: Royal Institute of San Luis; Mexico) |
| IRSL | Independent Roofing Supplies Ltd. (UK) |
| IRSL | International Roundtables for the Semiotics of Law |
| IRSL | Indo Rama Synthetics Ltd. (India; est. 1989) |
| IRSL | Initial Risk Screening Level (state air quality standard) |
| IRSL | Ingleburn RSL (Returned and Services League) Club (Australia) |
| IRSL | Interest Rate Sensitive Liabilities (banking) |
| IRSL | IR Stimulated Luminescence |
| IRSL | Industrial Roofing Services Ltd. (est. 1973; Concord, Ontario, Canada) |