| Acronym | Definition |
|---|
| ISAC | Illinois Student Assistance Commission |
| ISAC | Istituto di Scienze dell'Atmosfera e del Clima (Italy) |
| ISAC | Intelligent Secure Autonomic Controller |
| ISAC | Isa Client |
| ISAC | Iowa State Association of Counties |
| ISAC | International Society for Analytical Cytology |
| ISAC | Information Sharing Analysis Center |
| ISAC | International Scientific Advisory Committee |
| ISAC | Industry Sector Advisory Committee |
| ISAC | Information System Audit and Control (computing) |
| ISAC | ISRO Satellite Center (Indian Space Research Organisation) |
| ISAC | Information Society Activity Centre |
| ISAC | International Standard Accuracy Contest (Atlatl competition) |
| ISAC | Intelsat Solar Array Coupon (NASA) |
| ISAC | Infrastructure Sector Advisory Committee (US FEMA) |
| ISAC | Illinois State Advisory Council on the Education of Children with Disabilities |
| ISAC | Isotope Separator and Accelerator Facility (Triumf, University of British Columbia) |
| ISAC | Information Systems Work and Analysis of Changes |
| ISAC | Intelligent Secure Autonomic Controller (Symbium) |
| ISAC | Intermediate Systems Acquisition Course (DSMC) |
| ISAC | Indian Satellite Applications Center |
| ISAC | Information Sharing and Assessment Center (60 Private Companies) |
| ISAC | Internal Scientific Advisory Committee |
| ISAC | ISDN Subscriber Access Circuit |
| ISAC | Installation Support Agreement Catalog (various locations) |